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Zheng et al., CES1 -triggered liver-specific cargo release of CRISPR/Cas9 elements by cationic triadic copolymeric nanoparticles targeting gene editing of PCSK9 for hyperlipidemia amelioration

Front Genet 14:1289793

2c, Extended Data Fig

The mechanism is that fistein inhibits GSK-3 , which activates - Catenin, which leads to melanogenesis by activating MITF and tyrosinase (Molagoda et al., 2020)